抗糖皮质激素（ZK 98299）对乳鼠胸腺发育、氢化可的松诱导的胸腺溶解、肠刷状缘酶及其去唾液酸化的影响。

The effect of an anti-glucocorticoid (ZK 98299) on thymus evolution and on hydrocortisone-induced thymolysis, intestinal brush-border enzymes and their desialylation in suckling rats.

Kraml J, Kolínská J, Kadlecová L, Zákostelecká M, Hirsová D, Schreiber V

First Faculty of Medicine, Charles University, Prague, Czech Republic.

Adv Exp Med Biol. 1995;371A:537-41. doi: 10.1007/978-1-4615-1941-6_113.

Abstract

The action in Onapristone infant male rats displays short-term and delayed effects. 2. Suppression of intestinal brush-border enzymes and increase of thymus mass were observed only immediately after 3-day treatment with Onapristone. After an additional 3 days its effect disappeared. There was no immediate or delayed effect of Onapristone on the desialylation of brush-border enzymes. 3. In the short-term and delayed effects, Onapristone suppressed the HC-provoked induction of several intestinal brush-border enzymes, especially alpha-glycosidases. In the delayed effect the drug also suppressed thymolysis induced by the exogeneously given glucocorticoid, and suppressed the HC-induced desialylation of a brush-border enzyme DP IV, which serves as a marker of the desialylation process. 4. These experiments seem to support a conclusion that the postnatal development of intestinal brush-border enzymes and the development of thymus in infant rats are controlled by endogeneously secreted glucocorticoids. 5. The control of sialylation of intestinal brush-border proteins by endogeneously secreted glucocorticoids during the postnatal development of the rat remains debatable.

摘要

孕三烯酮对雄性幼鼠的作用表现出短期和延迟效应。2. 仅在孕三烯酮3天治疗后立即观察到肠刷状缘酶的抑制和胸腺质量的增加。再过3天后其作用消失。孕三烯酮对刷状缘酶的去唾液酸化没有即时或延迟作用。3. 在短期和延迟效应中，孕三烯酮抑制了组胺酸引起的几种肠刷状缘酶的诱导，尤其是α-糖苷酶。在延迟效应中，该药物还抑制了外源性给予糖皮质激素诱导的胸腺溶解，并抑制了组胺酸诱导的作为去唾液酸化过程标志物的刷状缘酶DP IV的去唾液酸化。4. 这些实验似乎支持这样一个结论，即幼鼠肠刷状缘酶的出生后发育和胸腺的发育受内源性分泌的糖皮质激素控制。5. 在大鼠出生后发育过程中，内源性分泌的糖皮质激素对肠刷状缘蛋白唾液酸化的控制仍存在争议。