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[交感-肾上腺系统激活对大鼠儿茶酚胺肺内失活的影响]

[The effect of the activation of the sympathetic-adrenal system on the pulmonary inactivation of catecholamines in rats].

作者信息

Bonetskiĭ A A, Fedorov V I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1992 Feb;78(2):81-6.

PMID:1330737
Abstract

Norepinephrine extraction was found to be decreased in the lungs of immobilised rats. Administration of epinephrine to intact rats up to the same level in the blood plasma as after stress, induced an increase in the norepinephrine extraction by the lungs. The data obtained suggest that norepinephrine inactivation due to immobilisation stress is unrelated to the plasma epinephrine level. The role of the lungs in the maintenance of increased plasma of norepinephrine by means of decreasing its metabolic inactivation, is discussed.

摘要

研究发现,固定不动的大鼠肺中去甲肾上腺素的摄取量减少。给完整的大鼠注射肾上腺素,使其血浆中肾上腺素水平达到与应激后相同的水平,结果肺对去甲肾上腺素的摄取量增加。所获得的数据表明,固定应激导致的去甲肾上腺素失活与血浆肾上腺素水平无关。本文讨论了肺通过减少去甲肾上腺素的代谢失活来维持血浆中去甲肾上腺素水平升高的作用。

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