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[肾上腺切除术和化学性交感神经切除术对出血性应激时中枢神经系统儿茶酚胺含量的影响]

[Effect of adrenalectomy and chemical sympathectomy on the catecholamines content in the central nervous system in hemorrhagic stress].

作者信息

Shirinian E A, Avakian O M

出版信息

Vopr Med Khim. 1978 Mar-Apr;24(2):216-9.

PMID:664447
Abstract

Content of adrenaline, noradrenaline, dopamine and normetanephrine was estimated by means of trihydroxyindole method in samples of brain and its hypothalamic part from intact, adrenal- and sympathectomized rats within 15 min, 24 and 72 hrs after hemorrhagic stress (3% blood of body weight within 20 min). Stable increase in dopamine content was observed in brain at all the periods studied. Alterations in the noradrenaline turnover in central nervous system were related to the state of peripheral sympathoadrenal system at early posthemorrhagic steps; the phenomenon was not found at the later periods after stress.

摘要

采用三羟基吲哚法测定了完整、肾上腺切除及交感神经切除大鼠在出血性应激(20分钟内抽取体重3%的血液)后15分钟、24小时和72小时的脑及其下丘脑部分样本中肾上腺素、去甲肾上腺素、多巴胺和去甲变肾上腺素的含量。在所有研究时间段内,脑中多巴胺含量均出现稳定增加。在出血后早期,中枢神经系统去甲肾上腺素周转率的变化与外周交感肾上腺系统的状态有关;应激后期未发现此现象。

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