Pross S H, Nakano Y, Widen R, McHugh S, Newton C A, Klein T W, Friedman H
University of South Florida College of Medicine, Tampa 33612.
Int J Immunopharmacol. 1992 Aug;14(6):1019-27. doi: 10.1016/0192-0561(92)90146-c.
Delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, can suppress the immune response, both in vitro and in vivo. In the present study, THC was found to either up-regulate or down-regulate lymphocytes depending on the method of stimulation. When the mitogens concanavalin A (Con A) or phytohemagglutinin (PHA) were used to stimulate THC-treated splenocytes, a down-regulation of lymphocyte proliferation occurred, which reflected lower T-cell numbers in general and Ly2 positive cells specifically. When splenocytes were stimulated directly by using anti-CD3 antibody it was found that low concentrations of THC enhanced lymphocyte proliferation, T-cell numbers in general, and Ly2 cells specifically. These results emphasize that THC can either enhance or suppress aspects of the immune response, depending on the specific immune stimulants used and the specific parameter of immunity measured.
Δ-9-四氢大麻酚（THC）是大麻的主要精神活性成分，在体外和体内均可抑制免疫反应。在本研究中，根据刺激方法的不同，发现THC对淋巴细胞既有上调作用，也有下调作用。当使用促有丝分裂原刀豆球蛋白A（Con A）或植物血凝素（PHA）刺激经THC处理的脾细胞时，淋巴细胞增殖出现下调，这总体上反映了T细胞数量减少，特别是Ly2阳性细胞数量减少。当使用抗CD3抗体直接刺激脾细胞时，发现低浓度的THC可增强淋巴细胞增殖，总体上增加T细胞数量，特别是增加Ly2细胞数量。这些结果强调，根据所使用的特定免疫刺激剂和所测量的免疫特定参数，THC可以增强或抑制免疫反应的各个方面。
