Ross J N, Wright J T, Eskin S, Von Koch L, Normann N A
J Biomed Mater Res. 1976 Jul;10(4):583-94. doi: 10.1002/jbm.820100415.
Polyacrylonitrile fabric (Orlon) may by oxidized by heating in air, when it becomes black and carbonized. During the heat treatment, the fibers shrink; this shrinkage allows components such as diaphrams to be shaped around molds. Oxidation reduces the tensile strength by about 25% and also reduces the stiffness of the material. The oxidized Orlons was screened in tissue culture for possible cytotoxic effects. Finding none, patches of the material were sutured into the right atrium of dogs and examined after 48 hr. Because of encouraging results, 10 atrial patches, consisting of Dacron velour and oxidized Orlon side-by-side, were implanted into the right atrium of dogs. Five patches were backed with Silastic to render them impervious, and five with segmented polyurethane. The atrial patches were examined after 48 hr, and in all instances the oxidized Orlon part of the patch was coated with a thinner and smoother fibrin layer than was the Dacron velour half. a left ventricular bypass pump was fabricated from oxidized Orlon and spray-coated on the nonblood surface with segmented polyurethane. After 48 hr implantation in the chest cavity of a calf, pumping without systemic anticoagulation, the pump was found covered by a thin, smooth, firmly attached layer of fibrin.
聚丙烯腈织物（奥纶）在空气中加热时会被氧化，此时它会变黑并碳化。在热处理过程中，纤维会收缩；这种收缩使得诸如隔膜等部件能够围绕模具成型。氧化会使拉伸强度降低约25%，同时也会降低材料的硬度。对氧化后的奥纶进行组织培养筛选，以检测其可能的细胞毒性作用。未发现细胞毒性后，将该材料的贴片缝合到狗的右心房，并在48小时后进行检查。由于结果令人鼓舞，将由涤纶绒和氧化奥纶并排组成的10个心房贴片植入狗的右心房。5个贴片用硅橡胶衬里使其不透水，另外5个用分段聚氨酯衬里。48小时后检查心房贴片，在所有情况下，贴片的氧化奥纶部分比涤纶绒部分覆盖着更薄、更光滑的纤维蛋白层。用氧化奥纶制作了一个左心室旁路泵，并在非血液表面喷涂分段聚氨酯。在小牛胸腔内植入48小时后，在未进行全身抗凝的情况下进行泵送，发现该泵被一层薄而光滑、牢固附着的纤维蛋白层覆盖。
