Felix R W, Sigel B, Gibson R J, Williams J, Popky G L, Edelstein A L, Justin J R
J Clin Ultrasound. 1976 Aug;4(4):275-82. doi: 10.1002/jcu.1870040409.
Pulsed Doppler ultrasound blood flow detection has been used in a noninvasive manner to detect arterial abnormalities associated with arteriosclerosis. Sound spectrograms of ultrasound signals obtained from in vitro and animal studies in which flow was disturbed by obstacles placed in the flow stream showed a different distribution of energy over frequency than signals obtained from studies with no flow disturbances. Similar findings were seen clinically. A technique has been developed which can detect disturbed flow patterns resulting from partial occlusion in important superficial arteries (e.g. femoral and carotid) up to 15 cm distal to localized arterial wall abnormalities. Thirty-five arterial examinations of normal and arteriographically abnormal arteries in 12 patients revealed a sensitivity of 83 percent and a specificity of 61 percent. This study suggests that pulsed Doppler ultrasound may be useful as a screening technique for detection of arteriosclerotic lesions in major superficial arteries.
脉冲多普勒超声血流检测已被用于以非侵入性方式检测与动脉硬化相关的动脉异常。在体外和动物研究中，通过在血流中放置障碍物来干扰血流，所获得的超声信号声谱图显示出与无血流干扰研究中获得的信号相比，能量在频率上的分布不同。临床上也观察到了类似的发现。已经开发出一种技术，该技术可以检测重要浅表动脉（如股动脉和颈动脉）局部动脉壁异常远端达15厘米处因部分闭塞而导致的血流紊乱模式。对12例患者的正常动脉和血管造影异常动脉进行的35次动脉检查显示，敏感性为83%，特异性为61%。这项研究表明，脉冲多普勒超声可能作为一种筛查技术，用于检测主要浅表动脉的动脉硬化病变。
