van Merode T, Hick P J, Hoeks A P, Reneman R S
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
Ultrasound Med Biol. 1988;14(6):459-64. doi: 10.1016/0301-5629(88)90105-6.
The diagnostic accuracy of noninvasive detection of carotid artery lesions with a diameter of less than 50% (minor to moderate) and greater than 50% reduction (severe) with the use of a multi-gate pulsed Doppler system (spectral analysis combined with the detection of flow disturbances) was studied in patients with focal neurological symptoms. Biplane arteriography was used as a reference. For all lesions the diagnostic accuracy (observed agreement), sensitivity and specificity was 88, 92, and 84%, respectively, and 84, 83, and 84%, respectively, when only minor to moderate lesions were considered. Kappa, a chance-corrected measure of agreement, which takes into account the marginal distribution of the data and, hence, may be considered to be a better parameter to describe diagnostic accuracy, was found to be 82.2%. The results in this study compare favorably with those obtained in studies employing duplex techniques (B-mode image combined with single-gate pulsed Doppler) and indicate that minor to moderate carotid artery lesions are detected rather accurately with the use of a multi-gate pulsed Doppler system.
在有局灶性神经症状的患者中，研究了使用多门脉冲多普勒系统（频谱分析结合血流紊乱检测）对直径减少小于50%（轻度至中度）和大于50%（重度）的颈动脉病变进行无创检测的诊断准确性。双平面动脉造影用作对照。对于所有病变，诊断准确性（观察到的一致性）、敏感性和特异性分别为88%、92%和84%，而仅考虑轻度至中度病变时，分别为84%、83%和84%。Kappa是一种考虑了数据边缘分布的一致性机会校正测量方法，因此可被视为描述诊断准确性的更好参数，其值为82.2%。本研究的结果与采用双功技术（B型图像结合单门脉冲多普勒）的研究结果相比更具优势，表明使用多门脉冲多普勒系统能相当准确地检测出轻度至中度颈动脉病变。
