Brunelleschi S, Ceni E, Fantozzi R, Maggi C A
Dept. Pharmacology, Univ. Florence, Firenze, Italy.
Life Sci. 1992;51(20):PL177-81. doi: 10.1016/0024-3205(92)90626-z.
Mammalian tachykinins dose-dependently activate guinea-pig alveolar macrophages, by interacting with tachykinin NK-2 receptors, mainly. By evaluating the effects of different NK-2 tachykinin receptor antagonists, we now provide evidence that tachykinin NK-2 receptors in guinea-pig alveolar macrophages meet the pharmacological criteria used to define the NK-2B subtype.
