Taveira Da Silva A M, Pineo S, Gillis R A
Department of Medicine and Pharmacology, Georgetown University Medical Center, Washington, D.C. 20007.
Pharmacology. 1992;45(3):154-61. doi: 10.1159/000138993.
Intravenous administration of midazolam (2 mg/kg) to 8 pentobarbital-anesthetized cats produced a significant decrease in minute ventilation, tidal volume, blood pressure and heart rate. Treatment with the gamma-aminobutyric acid (GABA) type A receptor antagonist bicuculline (10 micrograms/side) at the intermediate area of the ventral surface of the medulla (VSM) oblongata completely reversed the cardiorespiratory depressant effects of intravenous midazolam. In contrast, treatment with bicuculline at the same area failed to counteract the respiratory depressant effects of intravenous morphine (1 mg/kg). We conclude that the cardiorespiratory depressant effects of intravenously administered midazolam are due to enhancement of GABAergic transmission at the intermediate area of the VSM.
对8只戊巴比妥麻醉的猫静脉注射咪达唑仑（2毫克/千克），可使分钟通气量、潮气量、血压和心率显著降低。在延髓腹侧面中间区域（VSM）用γ-氨基丁酸（GABA）A型受体拮抗剂荷包牡丹碱（10微克/侧）进行处理，可完全逆转静脉注射咪达唑仑的心肺抑制作用。相比之下，在同一区域用荷包牡丹碱处理未能抵消静脉注射吗啡（1毫克/千克）的呼吸抑制作用。我们得出结论，静脉注射咪达唑仑的心肺抑制作用是由于VSM中间区域GABA能传递增强所致。
