Yamada K A, McAllen R M, Loewy A D
Brain Res. 1984 Apr 9;297(1):175-80. doi: 10.1016/0006-8993(84)90556-0.
Application of gamma-aminobutyric acid (GABA) antagonist drugs (bicuculline, picrotoxinin) to the intermediate region of the ventral surface of the medulla oblongata of gallamine paralyzed, alpha-chloralose anesthetized cats produced a dose-dependent blockade of the baroreceptor reflex. GABA antagonists applied to the rostral and caudal areas did not block the baroreceptor reflex. When strychnine was applied to the ventral medulla, it did not block the baroreceptor reflex. The diffusion of [3H]bicuculline was studied by scintillation counting and autoradiography and found not to penetrate more than 2 mm from the ventral medullary surface. These results suggest that a GABAergic synapse lies within the first 2 mm of the ventral medulla and is involved in baroreceptor modulation of the sympathetic outflow.
将γ-氨基丁酸（GABA）拮抗剂药物（荷包牡丹碱、印防己毒素）应用于加拉明麻痹、α-氯醛糖麻醉的猫的延髓腹侧面中间区域，可产生剂量依赖性的压力感受器反射阻断。将GABA拮抗剂应用于延髓头端和尾端区域不会阻断压力感受器反射。当将士的宁应用于延髓腹侧面时，它不会阻断压力感受器反射。通过闪烁计数和放射自显影研究了[3H]荷包牡丹碱的扩散，发现其从延髓腹侧面穿透不超过2毫米。这些结果表明，一个GABA能突触位于延髓腹侧面的前2毫米内，并参与交感神经输出的压力感受器调节。
