体内暴露于紫外线辐射会增强鼠白血病病毒LP - BM5在小鼠获得性免疫缺陷综合征中的致病作用。

In vivo exposure to ultraviolet radiation enhances pathogenic effects of murine leukemia virus, LP-BM5, in murine acquired immunodeficiency syndrome.

作者信息

Brozek C M, Shopp G M, Ryan S L, Gillespie P M, Kusewitt D F, Rajagopalan M S, Ley K D, Ley R D

机构信息

Photomedicine Program, Lovelace Medical Foundation, Albuquerque, NM 87108.

出版信息

Photochem Photobiol. 1992 Sep;56(3):287-95. doi: 10.1111/j.1751-1097.1992.tb02162.x.

DOI:10.1111/j.1751-1097.1992.tb02162.x

PMID:1332087

Abstract

LP-BM5 murine leukemia virus (MuLV) induces an immunodeficiency syndrome (MAIDS) in C57BL/6 mice which resembles immunological abnormalities observed in early stages of human AIDS. In our study, MAIDS virus-infected mice were exposed to low doses of ultraviolet radiation (UVR) before and after virus inoculation and compared with MAIDS-infected but not UVR-exposed mice. In all tested parameters (blood IgM levels; mitogenic responses to PHA, ConA, LPS and anti-mu; MLR; antigenic response to SRBC; enlargement and histopathologic changes of the spleen) we observed the same trend: changes due to MAIDS infection were more pronounced in the UVR-exposed group than in the unexposed group. Statistically significant differences between these two groups were seen for mitogenic responses at two different time points after virus inoculation. These results demonstrate that in vivo UVR exposure enhances the immunosuppressive effects of a retroviral infection. UVR exposure may affect the progression of AIDS in a similar manner.

摘要

LP - BM5鼠白血病病毒（MuLV）在C57BL/6小鼠中诱发一种免疫缺陷综合征（MAIDS），该综合征类似于人类艾滋病早期所观察到的免疫异常。在我们的研究中，将感染MAIDS病毒的小鼠在病毒接种前后暴露于低剂量紫外线辐射（UVR），并与感染MAIDS但未暴露于UVR的小鼠进行比较。在所有测试参数（血液IgM水平；对PHA、ConA、LPS和抗μ的促有丝分裂反应；混合淋巴细胞反应；对SRBC的抗原反应；脾脏肿大和组织病理学变化）中，我们观察到相同的趋势：在暴露于UVR的组中，由MAIDS感染引起的变化比未暴露组更明显。在病毒接种后的两个不同时间点，这两组在促有丝分裂反应方面存在统计学上的显著差异。这些结果表明，体内UVR暴露增强了逆转录病毒感染的免疫抑制作用。UVR暴露可能以类似方式影响艾滋病的进展。