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[视觉刺激在吗啡强化所致位置偏爱形成中的作用]

[The role of visual stimuli in the acquisition of place preference with morphine reinforcement].

作者信息

Tsibul'skiĭ V L, Belyĭ M V, Surkova L A, Belyĭ V P

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Jul-Aug;42(4):679-86.

PMID:1332286
Abstract

In experiments with rats was studied the role of visual stimuli in conditioning of place preference in a T-shaped chamber, certain stimuli being combined with morphine injection (5 mg/kg). Intensity of illumination of the chamber sections, colour of walls, and the orientation of dark stripes on the walls were varied. Testing the animals' behaviour began with determining the reward properties of certain visual stimuli on the basis of the total time of the animals' stay in a chamber. Procedure of combining the visual stimuli with morphine was repeated four times. Associative properties of the stimuli were revealed by comparing the learning efficiency in different experimental groups. Learning within the framework of the place preference model was concluded to depend upon the reward properties of the visual stimuli, whereas the behaviour itself to be based on the mechanism of the instrumental but not the classical conditioned response.

摘要

在对大鼠进行的实验中,研究了视觉刺激在T形实验箱中位置偏好条件反射中的作用,某些刺激与吗啡注射(5毫克/千克)相结合。实验箱各部分的光照强度、墙壁颜色以及墙壁上暗条纹的方向都有所变化。通过测定动物在实验箱中的停留总时间来确定某些视觉刺激的奖励特性,从而开始测试动物的行为。视觉刺激与吗啡相结合的过程重复了四次。通过比较不同实验组的学习效率,揭示了刺激的联想特性。得出结论,在位置偏好模型框架内的学习取决于视觉刺激的奖励特性,而行为本身则基于工具性条件反应机制而非经典条件反应机制。

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