Kopytova F V, Krivitskaia G N, Mednikova Iu S
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Jul-Aug;42(4):710-9.
Extracellular neuronal activity was recorded from 460 neurons from alert young (5-7 months), middle-aged (54-65 months) and old (66-85 months) rabbits. Trace rhythmic activity of sensorimotor cortical neurons was examined after long-lasting (10-20 min) rhythmic (0.5-2 Hz) electrocutaneous stimulation of the contralateral forelimb. Spectral analysis of spike activity showed age-related differences in capability of producing a rhythm of previous stimulation in spontaneous neuronal activity. In young animals propriate rhythmic fluctuations of firing rate appeared after the first or second sessions of stimulations (on the first experimental day), in middle-aged ones--after 2-4 sessions (on the second or third days); cortical neurons in old rabbits did not exhibit trace rhythmic activity. Significant morphological changes in glial and neuronal cells were observed in sensorimotor cortex of old rabbits. It is proposed that morphological deteriorations may be the reason of the impairement of trace processes during aging.
从清醒的年轻（5 - 7个月）、中年（54 - 65个月）和老年（66 - 85个月）兔的460个神经元记录细胞外神经活动。在对侧前肢进行长时间（10 - 20分钟）有节奏（0.5 - 2赫兹）的皮肤电刺激后，检查感觉运动皮层神经元的追踪节律活动。对峰电位活动的频谱分析显示，在自发神经活动中产生先前刺激节律的能力存在年龄相关差异。在年轻动物中，在第一次或第二次刺激时（在第一个实验日）就出现了适当的放电频率节律波动，中年动物在2 - 4次刺激后（在第二个或第三个实验日）出现；老年兔的皮层神经元未表现出追踪节律活动。在老年兔的感觉运动皮层观察到神经胶质细胞和神经元细胞有明显的形态学变化。有人提出，形态学恶化可能是衰老过程中追踪过程受损的原因。
