Silakov V L, Nikitin V S, Moiseeva L A, Losev S S, Perepelkin P D
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Jul-Aug;42(4):734-42.
Effects of relanium and oxytocin on higher nervous activity was studied in four rhesus monkeys (Macaca mulatta) and two baboons (Papio hamadryas). During observation of the animals in enclosure tranquilizing effect was seen only after relanium administration. Under the same conditions oxytocin practically did not change the general behaviour pattern of monkeys. However, steady behavioural transformations were observed under the conditions of competitive food-procuring behaviour and during the operant goal-directed reaction. Decreasing aggressiveness of dominants oxytocin in contrast to relanium had no negative effect upon their general motor activity and sensory perception. Differences in effects of the tranquilizer and the peptide were seen also at the unit activity level of the neurons. The first drug lowered the unit activity level and the degree of the functional connections in neuronal populations in a number of cortical structures. Administration of the second one led to selective shifts of the unit activity mainly in the frontal cortex of the monkeys.
在四只恒河猴（猕猴）和两只狒狒（阿拉伯狒狒）身上研究了雷拉尼姆和催产素对高级神经活动的影响。在围栏中观察动物时，仅在给予雷拉尼姆后才观察到镇静作用。在相同条件下，催产素实际上并未改变猴子的一般行为模式。然而，在竞争性食物获取行为条件下和操作性目标导向反应期间观察到了稳定的行为转变。与雷拉尼姆相比，催产素降低优势个体的攻击性，对其一般运动活动和感觉知觉没有负面影响。在神经元的单位活动水平上也观察到了镇静剂和肽的作用差异。第一种药物降低了许多皮质结构中神经元群体的单位活动水平和功能连接程度。第二种药物的给药主要导致猴子额叶皮质中单位活动的选择性变化。
