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[长期摄入乙醇对嗜杀(攻击性)大鼠生理状态及脑肽酶活性变化的影响]

[The effect of prolonged ethanol consumption on the physiological status and changes in brain peptidase activity of muricidal (aggressive) rats].

作者信息

Gomazkov O A, Panfilov A D, Komissarova N V, Rostovtsev A P

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Jul-Aug;42(4):771-8.

PMID:1332298
Abstract

Muricidal and non-muricidal Wistar rats were studied regarding the changes of the body weight, the volume of the liquid intake, the sensitivity threshold to electrical shock, horizontal and vertical locomotor activity during 40-days period of 20% ethanol consumption. The transition to the situation of "choice" (water and/or ethanol) was accompanied by a division of the animals into two groups: "water preferring" and "ethanol-preferring" rats. The angiotensin-converting enzyme and enkephalin-forming carboxypeptidase H activity in different brain regions, hypophysis and peripheral tissues, were defined. The results allow one to conclude that neurochemical mechanisms underlying aggressive behavior (muricidity) and alcohol addiction have originally distinct nature.

摘要

对有杀鼠行为和无杀鼠行为的Wistar大鼠进行了研究,观察在40天饮用20%乙醇期间体重、液体摄入量、电击敏感性阈值、水平和垂直运动活动的变化。向“选择”(水和/或乙醇)情境的转变伴随着动物分为两组:“偏好水”和“偏好乙醇”的大鼠。测定了不同脑区、垂体和外周组织中的血管紧张素转换酶和生成脑啡肽的羧肽酶H活性。结果表明,攻击行为(杀鼠行为)和酒精成瘾背后的神经化学机制原本具有不同的性质。

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