Kraicer J, Morris A R
Neuroendocrinology. 1976;21(2):175-92. doi: 10.1159/000122524.
Studies were carried out to test the responsiveness of dispersed pars intermedia (PI) cells to a number of neurotransmitter substances known to be present in the PI. These substances were tested over an extended dose range. The catecholamines, adrenaline, noradrenaline, and dopamine inactivated PI ACTH at high concentrations; at lower concentrations, they were without effect. Histamine and carbachol had no effect on ACTH release. 5-hydroxytryptamine stimulated ACTH release in a dose-related manner, from 10(-6) to 10(-3)M, while having no effect on ACTH release from the pars distalis (PD). We conclude that the release of ACTH from the PI may be controlled by direct serotonergic innervation.
开展了多项研究，以测试分散的中间部（PI）细胞对已知存在于PI中的多种神经递质物质的反应性。在较宽的剂量范围内对这些物质进行了测试。儿茶酚胺、肾上腺素、去甲肾上腺素和多巴胺在高浓度时可使PI促肾上腺皮质激素（ACTH）失活；在较低浓度时则无作用。组胺和卡巴胆碱对ACTH释放无影响。5-羟色胺以剂量相关的方式刺激ACTH释放，浓度范围为10（-6）至10（-3）M，而对远侧部（PD）的ACTH释放无影响。我们得出结论，PI中ACTH的释放可能受直接的5-羟色胺能神经支配控制。
