大鼠垂体神经中间叶促肾上腺皮质激素释放的体外调节。II. 神经递质的作用。

In vitro regulation of ACTH release from neurointermediate lobe of rat hypophysis. II. Effect of neurotransmitters.

作者信息

Briaud B, Koch B, Lutz-Bucher B, Mialhe C

出版信息

Neuroendocrinology. 1979;28(6):377-85. doi: 10.1159/000122886.

Abstract

The effect of various neurotransmitters on adrenocorticitropic hormone (ACTH) release from superfused neurointermediate lobes of rat hypophysis (NIL) was investigated. Acetylcholine, serotonin, and histamine were shown to have no significant effect on the spontaneous release of ACTH. In contrast, dopamine (DA) and noradrenaline (NA) stimulated NIL ACTH release in a dose-dependent manner. The stimulating effect of DA was mimicked by apomorphine and inhibited by haloperidol, whereas that of NA was abolished by phentolamine. In a comparative study, none of these neurotransmitters is shown to have any significant stimulating effect on ACTH release from superfused anterior lobes. It is concluded that the ACTH release from NIL might be controlled, at least in part, by catecholaminergic innervation.

摘要

研究了各种神经递质对大鼠垂体神经中间叶（NIL）超融合后促肾上腺皮质激素（ACTH）释放的影响。结果显示，乙酰胆碱、5-羟色胺和组胺对ACTH的自发释放无显著影响。相反，多巴胺（DA）和去甲肾上腺素（NA）以剂量依赖的方式刺激NIL的ACTH释放。阿扑吗啡可模拟DA的刺激作用，氟哌啶醇可抑制该作用，而酚妥拉明可消除NA的刺激作用。在一项对比研究中，这些神经递质均未对超融合前叶的ACTH释放产生任何显著的刺激作用。得出的结论是，NIL的ACTH释放可能至少部分受儿茶酚胺能神经支配的控制。