Wolff-Korman P G, Kormann B A, Hasenfratz G C, Spengel F A
University Eye Hospital, Munich, Germany.
Acta Ophthalmol Suppl (1985). 1992(204):66-70. doi: 10.1111/j.1755-3768.1992.tb04928.x.
There is paucity of data on the value of neovascular blood flow measurements in the differential diagnosis of human choroidal tumors, mainly due to difficulties in quantitating tumor vascularity in vivo. Color Doppler imaging and Duplex ultrasound, the combination of B-mode ultrasound and pulse Doppler analysis, were used to quantify tumor blood flow in 103 untreated tumors of the choroid. Pulsatile blood flow was detected at the tumor base of 62 choroidal melanomas (tumor height (TH) 3.1-11.7 mm) with a mean peak systolic frequency (MPSF) of 0.98 kHz (range 0.3-2.7 kHz). Compared to melanomas pulsatile neovascular flow in choroidal metastases (TH 2.1-6.5 mm, n = 12) was significantly higher (MPSF 1.87 kHz, range 0.8-3.5 kHz). No Doppler signals were elicited from age-related macular degeneration (n = 9), choroidal nevus (TH 1.5-2.1 mm, n = 18) and choroidal osteoma (n = 2). The results indicate that the quantitative measurement of tumor blood flow by duplex and color Doppler ultrasound may serve as a new diagnostic tool in the evaluation of intraocular tumors.
关于新生血管血流测量在鉴别诊断人类脉络膜肿瘤中的价值的数据较少，主要是因为在体内定量肿瘤血管存在困难。彩色多普勒成像和双功超声，即B型超声和脉冲多普勒分析的结合，被用于对103例未经治疗的脉络膜肿瘤的肿瘤血流进行定量。在62例脉络膜黑色素瘤（肿瘤高度（TH）3.1 - 11.7 mm）的肿瘤基底检测到搏动性血流，平均收缩期峰值频率（MPSF）为0.98 kHz（范围0.3 - 2.7 kHz）。与黑色素瘤相比，脉络膜转移瘤（TH 2.1 - 6.5 mm，n = 12）中的搏动性新生血管血流明显更高（MPSF 1.87 kHz，范围0.8 - 3.5 kHz）。年龄相关性黄斑变性（n = 9）、脉络膜痣（TH 1.5 - 2.1 mm，n = 18）和脉络膜骨瘤（n = 2）未引出多普勒信号。结果表明，双功和彩色多普勒超声对肿瘤血流的定量测量可能作为评估眼内肿瘤的一种新的诊断工具。
