Wolff-Kormann P G, Kormann B A, Riedel K G, Hasenfratz G C, Stefani F H, Spengel F A, Lund O E
University Eye Hospital, Munich, FRG.
Invest Ophthalmol Vis Sci. 1992 May;33(6):1928-33.
Histological data indicate the importance of tumor vascularization as a determinant of the biological behavior and the response to radiotherapy in choroidal melanoma. Duplex ultrasound and color Doppler imaging, the combination of B-mode ultrasound and pulse-waved Doppler analysis, were used to measure quantitatively neovascular blood flow in 31 patients with choroidal melanoma. Follow-up studies (20 patients) were performed to investigate the change of tumor blood flow in choroidal melanomas after radiotherapy. Blood flow was detected in 30 out of 31 melanomas (size 3.1-17.8 mm) within the tumor and at the tumor base with a mean peak systolic frequency of 1.0 kHz (range 0.3-2.7 kHz), a mean end diastolic frequency of 0.3 kHz (range 0.1-1.0 kHz), and a mean frequency of 0.7 kHz (range 0.2-1.3 kHz). Two and six months after 106Ru/106Rh beta-ray application, 19 patients showed a significant decrease in peak systolic frequency. This occurred with and in advance of the decrease in the tumor size. In one patient, a rising maximum systolic frequency after radiotherapy marked a recurrent tumor growth. Results indicate that the quantitative measurement of tumor blood flow by duplex ultrasound and color Doppler imaging may be a new diagnostic modality for monitoring the effectiveness of radiotherapy in choroidal melanoma.
组织学数据表明，肿瘤血管生成在脉络膜黑色素瘤的生物学行为及对放疗的反应中起着决定性作用。采用双功超声和彩色多普勒成像（B型超声与脉冲波多普勒分析相结合）对31例脉络膜黑色素瘤患者的新生血管血流进行定量测量。对20例患者进行随访研究，以观察放疗后脉络膜黑色素瘤肿瘤血流的变化。在31例黑色素瘤（大小为3.1 - 17.8 mm）中的30例肿瘤内部及肿瘤基底部检测到血流，平均收缩期峰值频率为1.0 kHz（范围0.3 - 2.7 kHz），平均舒张末期频率为0.3 kHz（范围0.1 - 1.0 kHz），平均频率为0.7 kHz（范围0.2 - 1.3 kHz）。在应用106Ru/106Rhβ射线后2个月和6个月，19例患者的收缩期峰值频率显著降低。这发生在肿瘤大小减小之前及同时。1例患者放疗后最大收缩期频率升高，提示肿瘤复发。结果表明，通过双功超声和彩色多普勒成像对肿瘤血流进行定量测量，可能是监测脉络膜黑色素瘤放疗效果的一种新的诊断方法。
