Ross E V, Roman L, Rushin J M, Cobb M W, Friedman K J
Department of Dermatology, National Naval Medical Center, Bethesda, Md.
Arch Dermatol. 1992 Nov;128(11):1499-502.
Lipoprotein-T-cell interactions are being reported with increasing frequency, and there is evidence that lipoproteins play a role in immunoregulation. We describe a patient with mycosis fungoides and hyperlipidemia who developed xanthomatization in one preexisting plaque. The case is unique in that some of the lipidized cells were atypical T cells. In previously reported cases of mycosis fungoides with dystrophic xanthomatosis, the lipid-containing cells have been identified only as histiocytes.
Immunopathologic features, electron microscopy, and lipid stains of the xanthomatized plaque demonstrated that some of the lipid-laden cells were atypical T cells.
In mycosis fungoides, malignant T cells may be intimately involved in processing of tissue lipids. We suggest that low-density lipoprotein receptors on activated T cells facilitated the cytoplasmic lipidization in this case.
脂蛋白与T细胞相互作用的报道日益增多，且有证据表明脂蛋白在免疫调节中发挥作用。我们描述了一名蕈样肉芽肿合并高脂血症患者，其一处原有的斑块出现了黄瘤化。该病例的独特之处在于，一些脂质化细胞为非典型T细胞。在先前报道的蕈样肉芽肿伴营养不良性黄瘤病病例中，含脂质细胞仅被鉴定为组织细胞。
对黄瘤化斑块进行免疫病理特征、电子显微镜检查及脂质染色显示，一些载脂细胞为非典型T细胞。
在蕈样肉芽肿中，恶性T细胞可能密切参与组织脂质的处理过程。我们认为，在该病例中，活化T细胞上的低密度脂蛋白受体促进了细胞质脂质化。
