Skeie B, Petersen A J, Manner T, Askanazi J, Jellum E, Steen P A
Department of Anesthesiology, Ullevaal Hospital, University of Oslo, Norway.
Pharmacol Biochem Behav. 1992 Nov;43(3):669-71. doi: 10.1016/0091-3057(92)90393-t.
During infusion of branched-chain amino acids (BCAAs) in humans, changes in ventilatory drive, appetite, and sleep have been reported. The mechanism by which BCAAs exert their effects on CNS remains unclear. Picrotoxin is a proconvulsant drug, acting as an antagonist on the GABA-benzodiazepine receptor complex. Twenty rats were randomized to receive either an IP injection with 4% BCAAs (300 mg/kg; 8 ml/kg) (n = 10) or placebo (saline 8 ml/kg) (n = 10). The mean latency time from injection to onset of seizures was recorded as an indication of the seizure threshold. Latency time was significantly longer for BCAAs than for placebo, 11.2 (+/- 1.9) vs. 8.3 (+/- 1.8) min. Thus, a BCAA injection increased the seizure threshold to picrotoxin (p < 0.03). This suggests that BCAA infusion may exert effects on the GABA-benzodiazepine receptor complex.
在人体输注支链氨基酸（BCAAs）期间，已报道通气驱动、食欲和睡眠会发生变化。BCAAs对中枢神经系统发挥作用的机制尚不清楚。印防己毒素是一种惊厥诱发药物，作为GABA-苯二氮䓬受体复合物的拮抗剂起作用。将20只大鼠随机分为两组，一组腹腔注射4%的BCAAs（300毫克/千克；8毫升/千克）（n = 10），另一组注射安慰剂（生理盐水8毫升/千克）（n = 10）。记录从注射到癫痫发作开始的平均潜伏时间，作为癫痫发作阈值的指标。BCAAs组的潜伏时间明显长于安慰剂组，分别为11.2（±1.9）分钟和8.3（±1.8）分钟。因此，注射BCAAs可提高对印防己毒素的癫痫发作阈值（p < 0.03）。这表明输注BCAAs可能对GABA-苯二氮䓬受体复合物产生影响。
