Skeie B, Petersen A J, Manner T, Askanazi J, Steen P A
Department of Anesthesiology, Rikshospitalet, University of Oslo, Norway.
Pharmacol Biochem Behav. 1994 May;48(1):101-3. doi: 10.1016/0091-3057(94)90504-5.
During infusion of branched-chain amino acids (BCAAs) in humans, changes in ventilatory drive, sleeping pattern, and appetite have been reported. The mechanism by which BCAA exerts their effects on CNS remains unclear. An infusion of a BCAA solution (300 mg/kg) has previously been found to increase the seizure threshold in rats to the proconvulsant drug picrotoxin, an antagonist on the GABA-benzodiazepine receptor complex. In this study, each of the BCAAs given separately (valine, leucine, isoleucine; 300 mg/kg) (n = 10) increased the mean latency time to onset of seizures vs. placebo as an indication of an increased seizure threshold. A balanced amino acid solution (Vamin-Glucose) had no effect on the seizure threshold. Thus, these CNS effects are specific for BCAAs and occur with all three.
在给人类输注支链氨基酸（BCAAs）期间，已有报告称通气驱动、睡眠模式和食欲会发生变化。BCAAs对中枢神经系统产生作用的机制尚不清楚。此前发现，输注BCAA溶液（300毫克/千克）可提高大鼠对惊厥药物印防己毒素（一种GABA-苯二氮䓬受体复合物拮抗剂）的惊厥阈值。在本研究中，单独给予的每种BCAAs（缬氨酸、亮氨酸、异亮氨酸；300毫克/千克）（n = 10）与安慰剂相比，均增加了癫痫发作的平均延迟时间，这表明惊厥阈值有所提高。平衡氨基酸溶液（凡命-葡萄糖）对惊厥阈值没有影响。因此，这些中枢神经系统效应是BCAAs所特有的，且三种BCAAs都会出现这种效应。
