Freund R, Dubensky T, Bronson R, Sotnikov A, Carroll J, Benjamin T
Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115.
Virology. 1992 Dec;191(2):724-31. doi: 10.1016/0042-6822(92)90248-n.
We have determined the tumor responses of nine inbred mouse strains and of two F1 hybrids following inoculation with polyoma virus. The results showed wide variations in the frequencies of mice developing tumors. Correlation with H-2 haplotype were evident. C3H/BiDa mice of H-2k type were fully susceptible, while C57BL/6 mice of H-2b type were completely resistant. DBA/2 and BALB/c mice, both H-2d, were of low susceptibility. Contributions of the major histocompatibility complex were demonstrated using pairs of H-2 congenic mice. Substitution of H-2k on either a BALB/c or a C57BL/10 background resulted in an increase in the frequencies and kinds of tumors induced. Susceptibilities of BALB and C57BL mice bearing the H-2k haplotype were still well below those of C3H/BiDa mice, however. Crosses of C3H/BiDa with BALB/c or BALB.K (H-2k) produced F1s that were of moderate and full susceptibility, respectively. These results indicate two distinct classes of host genes, one at the H-2 locus where different alleles confer varying degrees of resistance and the other a dominant susceptibility gene(s) carried in C3H/BiDa mice.
我们已确定了9种近交系小鼠品系和2种F1杂种小鼠在接种多瘤病毒后的肿瘤反应。结果显示，发生肿瘤的小鼠频率存在广泛差异。与H-2单倍型的相关性很明显。H-2k型的C3H/BiDa小鼠完全易感，而H-2b型的C57BL/6小鼠则完全抗性。H-2d的DBA/2和BALB/c小鼠易感性较低。使用成对的H-2同源小鼠证明了主要组织相容性复合体的作用。在BALB/c或C57BL/10背景上替换H-2k会导致诱导的肿瘤频率和种类增加。然而，携带H-2k单倍型的BALB和C57BL小鼠的易感性仍远低于C3H/BiDa小鼠。C3H/BiDa与BALB/c或BALB.K（H-2k）杂交产生的F1分别具有中等和完全易感性。这些结果表明存在两类不同的宿主基因，一类在H-2位点，不同等位基因赋予不同程度的抗性，另一类是C3H/BiDa小鼠携带的显性易感基因。
