对多瘤病毒感染的免疫：多瘤病毒-小鼠模型
Immunity to polyomavirus infection: the polyomavirus-mouse model.
作者信息
Swanson Phillip A, Lukacher Aron E, Szomolanyi-Tsuda Eva
机构信息
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Semin Cancer Biol. 2009 Aug;19(4):244-51. doi: 10.1016/j.semcancer.2009.02.003. Epub 2009 Feb 14.
Abstract
A ubiquitous clinically silent murine pathogen, polyomavirus has enjoyed long-term co-evolution with the mouse, a highly tractable and genetically and immunologically informative small animal model. Thus, polyomavirus has provided a valuable experimental construct to decipher the host immune mechanisms that come into play to control systemic low-level persistent viral infections. Impaired immunosurveillance for infected cells puts the murine host at risk both to injury resulting from excessive direct virus cytolysis and development of virus-induced tumors. In this review, we present our current understanding of the multifaceted immune response invoked by the mouse to maintain détente with this potentially deleterious persistent natural pathogen, and discuss implications of these studies for therapeutic interventions for human polyomavirus infection.
摘要
多瘤病毒是一种普遍存在且临床上无症状的鼠类病原体，它与小鼠长期共同进化，小鼠是一种易于操作且在遗传学和免疫学方面信息丰富的小型动物模型。因此，多瘤病毒提供了一个有价值的实验框架，用于解读在控制全身性低水平持续性病毒感染过程中发挥作用的宿主免疫机制。对受感染细胞的免疫监视受损，使鼠类宿主面临因过度直接的病毒细胞溶解导致的损伤以及病毒诱导肿瘤发生的风险。在这篇综述中，我们阐述了目前对小鼠引发的多方面免疫反应的理解，这些反应旨在与这种潜在有害的持续性天然病原体保持缓和状态，并讨论了这些研究对人类多瘤病毒感染治疗干预的意义。
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