[抑制纤维生成的实验研究]
[Experimental studies of the inhibition of fibrogenesis].
作者信息
Böker K, Schwarting G, Kaule G, Günzler V, Ohlendorf S, Schmidt E
机构信息
Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Frankfurt/M.
出版信息
Z Gastroenterol. 1992 Mar;30 Suppl 1:43-5.
Colchicine as well HOE 077 were found to be effective in the inhibition of hepatic collagen accumulation after bile duct ligation in rats. The effect was additive and was truly reflected by changes in the serum PIIIP and 7s-collagen (IV) concentration. Extrahepatic effects on collagen synthesis were not detected when HOE 077 was used. Thus further studies on the potential clinical usefulness of these compounds are clearly indicated.
秋水仙碱以及HOE 077在抑制大鼠胆管结扎术后肝脏胶原积聚方面均被发现有效。这种作用是相加的，并且血清III型前胶原肽（PIIIP）和7s-胶原（IV）浓度的变化真实地反映了这一作用。当使用HOE 077时，未检测到对肝外胶原合成的影响。因此，显然需要对这些化合物潜在的临床用途进行进一步研究。
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