Mezey E, Palkovits M
Laboratory of Neuromorphology, Semmelweis University Medical School, Budapest, Hungary.
Science. 1992 Dec 4;258(5088):1662-5. doi: 10.1126/science.1333642.
The gastric mucosa consists of the epithelium, which lines the lumen, the lamina propria, and the muscularis mucosae. The targets of drugs used to treat stomach and duodenal ulcers are thought to be the acid-secreting parietal cells of the epithelium. However, immune cells in the lamina propria are the only cells that showed detectable messenger RNAs for histamine, muscarinic, gastrin, and dopamine receptors by in situ hybridization histochemistry. None of the epithelial cells expressed any of these messenger RNAs. Thus, the targets of antiulcer drugs seem to be cells of the immune system in the gut and not parietal cells, as generally believed. This conclusion may revise the thinking about ulcer formation and may shed light on the etiology of such chronic small intestinal diseases as Crohn's disease.
胃黏膜由内衬管腔的上皮、固有层和黏膜肌层组成。用于治疗胃和十二指肠溃疡的药物靶点被认为是上皮中分泌酸的壁细胞。然而，通过原位杂交组织化学，固有层中的免疫细胞是唯一显示出可检测到的组胺、毒蕈碱、胃泌素和多巴胺受体信使核糖核酸的细胞。上皮细胞均未表达这些信使核糖核酸中的任何一种。因此，抗溃疡药物的靶点似乎是肠道免疫系统的细胞，而非如普遍认为的壁细胞。这一结论可能会改变对溃疡形成的看法，并可能为诸如克罗恩病等慢性小肠疾病的病因提供线索。
