Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, 31-121 Krakow, Poland.
Int J Mol Sci. 2021 Nov 29;22(23):12932. doi: 10.3390/ijms222312932.
an increased prevalence of gastro-duodenal ulceration was described almost sixty years ago as prodromal to idiopathic Parkinson's disease, while duodenal ulcers have been rarely diagnosed in patients with schizophrenia. The cytoprotective role of dopamine in animal models of gastrointestinal ulcerations has also been described. Interestingly, Parkinson's disease (PD) might share common pathophysiological links with inflammatory bowel disease (IBD) as epidemiological and genetic links already suggest. Thus, the aim of our study was to review the existing literature on the role of the gastrointestinal dopaminergic system in IBD pathogenesis and progression.
a systematic search was conducted according to the PRISMA methodology.
twenty-four studies satisfied the predetermined criteria and were included in our qualitative analysis. Due to different observations (cross-sectional studies) as well as experimental setups and applied methodologies (in vivo and in vitro studies) a meta-analysis could not be performed. No ongoing clinical trials with dopaminergic compounds in IBD patients were found.
the impairment of the dopaminergic system seems to be a significant, yet underestimated, feature of IBD, and more in-depth observational studies are needed to further support the existing preclinical data.
大约六十年前，人们描述了胃十二指肠溃疡的患病率增加，这是特发性帕金森病的前驱症状，而精神分裂症患者的十二指肠溃疡则很少被诊断出来。多巴胺在动物胃肠道溃疡模型中的细胞保护作用也已被描述。有趣的是，帕金森病（PD）可能与炎症性肠病（IBD）具有共同的病理生理联系，因为流行病学和遗传联系已经表明了这一点。因此，我们的研究旨在综述胃肠道多巴胺能系统在 IBD 发病机制和进展中的作用的现有文献。
根据 PRISMA 方法进行了系统搜索。
符合预定标准的 24 项研究被纳入我们的定性分析。由于不同的观察（横断面研究）以及实验设置和应用的方法学（体内和体外研究），因此无法进行荟萃分析。未发现正在进行的 IBD 患者中使用多巴胺能化合物的临床试验。
多巴胺能系统的损伤似乎是 IBD 的一个重要但被低估的特征，需要更深入的观察性研究来进一步支持现有的临床前数据。
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