Sanders B, Collins A C, Wesley V H
Psychopharmacologia. 1976 Mar 16;46(2):159-62. doi: 10.1007/BF00421385.
Drugs which increase brain levels of serotonin (5-HT) have frequently been found to cause a decrease in voluntary ethanol consumption. Results obtained with parachlorophenylalanine (pCPA), which decreases 5-HT, have been less consistent. The present investigation compared the effects of pCPA on alcohol selection with those of pargyline, a monoamine oxidase inhibitor which increases brain levels of 5-HT. Ingestion of a 10% ethanol solution was assessed in male C57BL/6J mice given daily injections of 250 or 300 mg/kg pCPA, 50 mg/kg pargyline, or saline. An additional control group received no treatment. A two-bottle preference procedure was employed, and ethanol and water intake were recorded during a pretreatment period (11 days), a treatment period (8 days), and a posttreatment period (10 days). Like other agents which increase 5-HT, parygyline produced a depression in ethanol intake which lasted beyond the time of drug administration. pCPa had no effect on ethanol ingestion either during the period of drug administration or afterwards.
人们经常发现，能提高大脑中血清素（5-羟色胺，5-HT）水平的药物会导致自愿乙醇摄入量减少。而使用对氯苯丙氨酸（pCPA）降低5-HT水平所得到的结果却不太一致。本研究比较了pCPA与帕吉林（一种能提高大脑5-HT水平的单胺氧化酶抑制剂）对酒精选择的影响。在每天注射250或300mg/kg pCPA、50mg/kg帕吉林或生理盐水的雄性C57BL/6J小鼠中，评估其对10%乙醇溶液的摄取情况。另外设置一个未接受任何处理的对照组。采用双瓶偏好实验程序，记录预处理期（11天）、治疗期（8天）和治疗后期（10天）的乙醇和水摄入量。与其他提高5-HT的药物一样，帕吉林使乙醇摄入量降低，且这种作用在给药后仍持续存在。pCPA在给药期间及之后对乙醇摄取均无影响。
