[The pathways of the stabilization of the amplitude of postsynaptic potentials in the interneuronal synapses of vertebrates].

The influence of various factors on the degree of stabilization of postsynaptic potential amplitude has been studied by mathematical modelling. Increasing of transmitter release probability in single boutons, spatial non-uniformity of these probabilities, interaction of release sites, non-linear summation of potentials lead to amplitude stabilization. Temporal fluctuations of the release probability, failures of responses from contact groups and activation of a variable number of the fibers have the opposite influence. Comparison of synaptic transmission parameters in sensorimotor synapses of Cyclostomata, amphibians and mammals showed that during evolution of these synapses two different pathways of amplitude stabilization had been realized. Formation of highly effective chemical contacts is probably the most progressive pathway among them.