奈多罗米钠对离体兔迷走神经的作用。

The effect of nedocromil sodium on the isolated rabbit vagus nerve.

作者信息

Jackson D M, Pollard C E, Roberts S M

机构信息

Department of Pharmacology, Fisons Research and Development Laboratories, Loughborough, Leicestershire, UK.

出版信息

Eur J Pharmacol. 1992 Oct 6;221(1):175-7. doi: 10.1016/0014-2999(92)90790-b.

DOI:10.1016/0014-2999(92)90790-b

PMID:1333973

Abstract

Nedocromil sodium depolarized the isolated rabbit vagus nerve. The depolarization was blocked by DIDS (4,4'-diisothiocyanostilbene-2,2'-disulphonic acid) and did not occur when the nerve was bathed in solutions low in chloride. After depolarization the nerve was refractory to nedocromil sodium for an hour. It is suggested that nedocromil sodium can affect a chloride channel.

摘要

奈多罗米钠使离体兔迷走神经去极化。这种去极化被4,4'-二异硫氰基芪-2,2'-二磺酸（DIDS）阻断，并且当神经浸浴在低氯溶液中时不会发生。去极化后，神经对奈多罗米钠有一小时的不应期。提示奈多罗米钠可影响氯离子通道。