Jackson D M, Norris A A, Eady R P
Fisons plc, Pharmaceutical division, Loughborough, UK.
Pulm Pharmacol. 1989;2(4):179-84. doi: 10.1016/0952-0600(89)90018-5.
The effect of nedocromil sodium on the main sensory nerve types in the dog lung has been studied. Nedocromil sodium (0.1, 1.0 and 10 mg/kg i.v.) did not stimulate or inhibit the discharge pattern of pulmonary stretch receptors, rapidly adapting irritant receptors or pulmonary C-fibre endings. Nedocromil sodium 5 micrograms/kg given into the aortic arch did, however, stimulate bronchial C-fibre endings. These endings were also stimulated when the drug was given by aerosol. The possibility that nedocromil sodium suppresses cough in the dog by stimulation of bronchial C-fibre endings is discussed.
已对奈多罗米钠对犬肺主要感觉神经类型的作用进行了研究。奈多罗米钠（静脉注射0.1、1.0和10mg/kg）未刺激或抑制肺牵张感受器、快速适应性刺激感受器或肺C纤维末梢的放电模式。然而，将5微克/千克的奈多罗米钠注入主动脉弓时，确实刺激了支气管C纤维末梢。当通过气雾剂给药时，这些末梢也受到刺激。文中讨论了奈多罗米钠通过刺激支气管C纤维末梢抑制犬咳嗽的可能性。
