Gabrijelcic D, Svetic B, Spaić D, Skrk J, Budihna J, Turk V
Dept. of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia.
Agents Actions Suppl. 1992;38 ( Pt 2):350-7.
In 20 matched pairs, an increase of all cathepsins was measured in carcinoma tissue compared with normal tissue of the same breast. On contrary, the mean value for kininogen was almost 2 fold lower than mean value determined in normal cytosols. From all proteins tested, the amount of cathepsin B correlated mostly with the degree of malignancy inside the group of invasive ductal carcinoma (n = 90, p < 0.01).
在20对匹配样本中，与同一乳腺的正常组织相比，癌组织中所有组织蛋白酶的含量均有所增加。相反，激肽原的平均值几乎比正常细胞溶质中测定的平均值低2倍。在所有检测的蛋白质中，组织蛋白酶B的含量与浸润性导管癌组（n = 90，p < 0.01）内的恶性程度相关性最高。
