Kourouma K, Konde M K, Diallo M P, Conde M, Salomon H, Roussey M, Senecal J
Centre de formation et de recherches de Maférinyah, Guinée.
Ann Pediatr (Paris). 1992 Nov;39(9):566-71.
Measles immunization with the Edmonston Zagreb stain was carried out in 71 six-month-old infants. Proportions of subjects with immunity were 91% among the 47 subjects retested before one year of age and 100% among the 28 subjects retested between two and three years of age. These results support the WHO recommendation that measles immunization should be given at the age of six months. The concerns expressed by some about possible adverse effects of early measles immunization (decreased immune defenses) are discussed, as well as the transfer of maternal antibodies and persistence of these antibodies in the child. The obstacles to such studies in developing countries, including the need for repeated phlebotomies with centrifugation of specimens and freezing of sera, could be circumvented by the use of filter paper dried blood spot samples which seem to provide reliable results although with values somewhat lower than those found in frozen sera.
对71名六个月大的婴儿进行了用埃德蒙斯顿-萨格勒布毒株的麻疹免疫接种。在一岁前重新检测的47名受试者中，有免疫力的受试者比例为91%，在两岁至三岁之间重新检测的28名受试者中这一比例为100%。这些结果支持了世界卫生组织关于应在六个月龄时进行麻疹免疫接种的建议。文中讨论了一些人对早期麻疹免疫接种可能产生的不良反应（免疫防御能力下降）的担忧，以及母体抗体的转移和这些抗体在儿童体内的持续存在情况。在发展中国家进行此类研究存在一些障碍，包括需要反复进行静脉穿刺、对标本进行离心以及冷冻血清，而使用滤纸干血斑样本可以规避这些障碍，尽管其检测值略低于冷冻血清中的检测值，但滤纸干血斑样本似乎能提供可靠的结果。
