del Buono M B, Vaschetti P, Iannicelli J, Silber R
Hospital Interzonal de Agudos Especializado en Pediatría Superiora Sor María Ludovica, Calle 14 entre 65 y 66, 1900 La Plata, Provincia de Buenos Aires, Argentina.
Rev Argent Microbiol. 2003 Apr-Jun;35(2):102-5.
Measles outbreaks every 3-4 years have occurred in Argentina. The vaccine was introduced in 1978 as part of a regular program, and the age for the first vaccination was changed to one year old. The optimal age for first measles vaccination is defined as that age with the highest proportion of infants responding to the vaccine. It is dependent on the presence of maternal antibodies against measles virus and the maturation of the immune system. This paper reports the loss of maternal antibodies in infants from vaccinated mothers, attending at the Hospital I.A.E.P. Superiora Sor María Ludovica, La Piata, Argentina. To determine the IgG antibodies against measles virus, an ELISA test was used in a longitudinal follow up of 48 patients (4, 6 and 9 month-old infants). Only 18.7% of 4 month-old infants showed detectable levels of IgG antibodies against measles virus; this value declined to 4.2% in 6 month-old infants (p < 0.01) and measles virus antibodies were undetectable in 9 month-old infants. The extension of this study to a broader population is suggested, in order to reconsider the optimal age of the first measles vaccination.
阿根廷每3至4年就会爆发麻疹疫情。1978年，麻疹疫苗作为常规计划的一部分被引入，首次接种疫苗的年龄改为一岁。首次麻疹疫苗接种的最佳年龄定义为对疫苗产生反应的婴儿比例最高的年龄。它取决于母体抗麻疹病毒抗体的存在以及免疫系统的成熟程度。本文报告了在阿根廷拉普拉塔市圣母玛利亚·卢多维卡高级综合医院就诊的接种过疫苗的母亲所生婴儿体内母体抗体的消失情况。为了测定抗麻疹病毒的IgG抗体，对48名患者（4个月、6个月和9个月大的婴儿）进行了纵向随访，并采用了ELISA检测。4个月大的婴儿中只有18.7%显示出可检测到的抗麻疹病毒IgG抗体水平；这一数值在6个月大的婴儿中降至4.2%（p<0.01），而在9个月大的婴儿中未检测到麻疹病毒抗体。建议将这项研究扩展到更广泛的人群，以便重新考虑首次麻疹疫苗接种的最佳年龄。
