Romero G, Toscano E, Montero D, De Felipe M C, Del Rio J
Department of Pharmacology, University of Navarra Medical School, Pamplona, Spain.
J Neural Transm Gen Sect. 1992;90(2):113-24. doi: 10.1007/BF01250793.
Tianeptine, an antidepressant drug enhancing 5-HT uptake, was given to pregnant rats in the last 15 days of gestation and different neurotransmitter receptors as well as 5-HT2 receptor-linked inositol phosphate formation were measured in the brains of the offspring. Prenatal exposure to tianeptine significantly decreased the density of 3H-imipramine binding sites in the cerebral cortex of the pups without affecting beta-adrenoceptors, serotonin 5-HT2 and 5-HT1B receptors or inositol phosphate formation after a 5-HT challenge. Striatal dopamine D2 receptors labelled with 3H-spiroperidol were not changed but an apparent increase in the affinity of dopamine was noticed in the pups prenatally exposed to the drug. The results show that the neurochemical profile of tianeptine markedly differs from that of most antidepressants.
噻奈普汀是一种增强5-羟色胺（5-HT）摄取的抗抑郁药，在妊娠最后15天给予怀孕大鼠，然后检测其后代大脑中不同的神经递质受体以及与5-HT2受体相关的肌醇磷酸形成情况。产前接触噻奈普汀可显著降低幼崽大脑皮质中3H-丙咪嗪结合位点的密度，而在5-HT激发后，对β-肾上腺素能受体、5-羟色胺5-HT2和5-HT1B受体或肌醇磷酸形成无影响。用3H-螺哌啶醇标记的纹状体多巴胺D2受体未发生变化，但产前接触该药物的幼崽中，多巴胺的亲和力明显增加。结果表明，噻奈普汀的神经化学特征与大多数抗抑郁药明显不同。
