Montero D, De Felipe M C, Del Río J
Department of Neuropharmacology, Cajal Institute, CSIC, Madrid, Spain.
Eur J Pharmacol. 1991 Apr 24;196(3):327-9. doi: 10.1016/0014-2999(91)90448-y.
Acute or chronic treatment of young or adult rats with chlorimipramine, tianeptine or iprindole, antidepressants with different effects on 5-HT uptake mechanisms, did not modify the density or the affinity of 5-HT1B receptors of the frontal cortex. No significant receptor change was found after prenatal exposure to these antidepressants. The lack of effect of the antidepressants was not related to the density of 5-HT1B receptors, which was significantly lower in younger animals.
用氯米帕明、噻奈普汀或茚满二酮对幼年或成年大鼠进行急性或慢性治疗，这些抗抑郁药对5-羟色胺（5-HT）摄取机制有不同影响，但并未改变额叶皮质5-HT1B受体的密度或亲和力。产前接触这些抗抑郁药后未发现受体有显著变化。抗抑郁药缺乏效果与5-HT1B受体的密度无关，在较年幼动物中该受体密度显著较低。
