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产前暴露于抗抑郁药对大鼠脑内5-羟色胺刺激的磷酸肌醇水解及5-羟色胺2型受体的影响。

Effect of prenatal exposure to antidepressants on 5-HT-stimulated phosphoinositide hydrolysis and 5-HT2 receptors in rat brain.

作者信息

Romero G, Toscano E, Del Río J

机构信息

Department of Pharmacology, University of Navarra Medical School, Pamplona, Spain.

出版信息

Gen Pharmacol. 1994 Sep;25(5):851-6. doi: 10.1016/0306-3623(94)90086-8.

DOI:10.1016/0306-3623(94)90086-8
PMID:7835628
Abstract
  1. Female rats were given antidepressants, with different effects on 5-HT uptake, from day 6 of pregnancy until delivery. 2. 5-HT-stimulated inositol phosphate accumulation as well as 5-HT2 receptor density were measured at two different times in the pups. 3. Prenatal exposure to fluoxetine or iprindole reduced phosphoinositide hydrolysis in 25-day-old pups. However, chronic treatment of adult rats with fluoxetine or prenatal exposure to either desipramine or tianeptine did not modify inositol phosphate accumulation. 4. After prenatal exposure, only desipramine significantly decreased the density of [3H]ketanserin-labelled 5-HT2 receptors in the pups. 5. No correlation was found between changes in inositol phosphate formation and 5-HT2 receptor number.
摘要
  1. 从怀孕第6天到分娩，给雌性大鼠服用对5-羟色胺（5-HT）摄取有不同影响的抗抑郁药。2. 在幼崽的两个不同时间点测量5-HT刺激的肌醇磷酸积累以及5-HT2受体密度。3. 产前接触氟西汀或茚满二酮可降低25日龄幼崽的磷酸肌醇水解。然而，成年大鼠长期用氟西汀治疗或产前接触去甲丙咪嗪或噻奈普汀均未改变肌醇磷酸积累。4. 产前接触后，只有去甲丙咪嗪显著降低了幼崽中[3H]酮色林标记的5-HT2受体的密度。5. 未发现肌醇磷酸形成变化与5-HT2受体数量之间存在相关性。

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1
Effect of prenatal exposure to antidepressants on 5-HT-stimulated phosphoinositide hydrolysis and 5-HT2 receptors in rat brain.产前暴露于抗抑郁药对大鼠脑内5-羟色胺刺激的磷酸肌醇水解及5-羟色胺2型受体的影响。
Gen Pharmacol. 1994 Sep;25(5):851-6. doi: 10.1016/0306-3623(94)90086-8.
2
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Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain.孕期暴露于噻奈普汀对大鼠脑内不同神经递质受体及5-羟色胺刺激的肌醇磷酸生成的影响。
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5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors but this response does not reflect altered 5-HT2 function after 5,7-dihydroxytryptamine lesioning or repeated antidepressant treatments.5-羟色胺刺激小鼠皮层中肌醇磷脂水解，具有与通过5-HT2受体介导相符的药理学特性，但这种反应并不反映5,7-二羟色胺损伤或反复抗抑郁治疗后5-HT2功能的改变。
J Neurochem. 1988 Mar;50(3):730-8. doi: 10.1111/j.1471-4159.1988.tb02975.x.
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Desensitization and down-regulation of 5-HT2 receptors in P11 cells.P11细胞中5-羟色胺2型受体的脱敏与下调
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The effect of chronic ritanserin and clorgyline administration on 5-HT2 receptor linked inositol phospholipid hydrolysis.长期给予利坦色林和氯吉兰对5-羟色胺2（5-HT2）受体相关的肌醇磷脂水解的影响。
Biochem Pharmacol. 1990 Nov 1;40(9):2111-6. doi: 10.1016/0006-2952(90)90242-d.
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Prenatal exposure of rats to antidepressant drugs down-regulates beta-adrenoceptors and 5-HT2 receptors in cerebral cortex. Lack of correlation between 5-HT2 receptors and serotonin-mediated behaviour.大鼠在产前接触抗抑郁药物会下调大脑皮层中的β-肾上腺素能受体和5-HT2受体。5-HT2受体与血清素介导行为之间缺乏相关性。
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Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain.5-羟色胺摄取抑制剂氟西汀和西酞普兰重复治疗对大鼠脑内5-羟色胺1A和5-羟色胺2受体的影响。
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Evidence that chronic administration of paroxetine or fluoxetine enhances 5-HT2 receptor function in the brain of the guinea pig.
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Tandem regulation of phosphoinositide signaling and acute behavioral effects induced by antidepressant agents in rats.大鼠中磷酸肌醇信号传导的串联调节及抗抑郁药诱导的急性行为效应
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引用本文的文献

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Curr Neuropharmacol. 2011 Sep;9(3):478-511. doi: 10.2174/157015911796557957.
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Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring.孕期服用氟西汀或赋形剂对豚鼠后代行为结果的长期影响。
Psychopharmacology (Berl). 2005 Mar;178(2-3):328-38. doi: 10.1007/s00213-004-2003-7. Epub 2004 Sep 10.
3
Antidepressant use during pregnancy.
孕期使用抗抑郁药。
J Psychiatry Neurosci. 2001 Jan;26(1):17-9.