Osugi H, Higashino M, Kinoshita H, Shimonishi Y, Omura M, Ikeda H, Oda J, Ochi H
Department of Surgery, Osaka City University Medical School.
Kaku Igaku. 1992 Oct;29(10):1237-43.
To evaluate the function of deglutition quantitatively, radionuclide transit in the and upper esophagus was examined. Ten ml of water containing 185 MBq 99mTc pertechnetate was put into the mouth and isotopic counts were measured every 0.2 second in the oral cavity, upper and lower cervical esophagus, and upper mediastinum. The subjects were studied twice, once while sitting and once supine. Esophageal transit was evaluated with time-activity curves obtained in each region of interest. In twelve healthy volunteers transit of the radionuclide was significantly delayed in supine position compared with sitting position. Even while the subject was supine, the radionuclide was propelled into the lower cervical esophagus in 0.8 second and upper mediastinum in 1.4 second in the healthy volunteers. In the patient, who had reconstruction of the esophagus through posterior mediastinum, radionuclide transit was not different from that of healthy volunteers. Whereas in the patient, who had the reconstruction through retrosternal space, the transit was remarkably delayed. The esophageal scintigraphy was safe and sensitive enough to evaluated the function of deglutition quantitatively.
为了定量评估吞咽功能，对咽部和上段食管的放射性核素通过情况进行了检查。将含有185MBq高锝[99mTc]的10ml水放入口中，并在口腔、颈段食管上下段以及上纵隔每0.2秒测量一次同位素计数。对受试者进行了两次研究，一次坐着，一次仰卧。通过在每个感兴趣区域获得的时间-活性曲线评估食管通过情况。在12名健康志愿者中，与坐姿相比，仰卧位时放射性核素的通过明显延迟。即使在受试者仰卧时，健康志愿者中的放射性核素在0.8秒时被推进到颈段食管下段，在1.4秒时被推进到上纵隔。在通过后纵隔进行食管重建的患者中，放射性核素通过情况与健康志愿者无异。而在通过胸骨后间隙进行重建的患者中，通过明显延迟。食管闪烁扫描术安全且足够敏感，能够定量评估吞咽功能。
