Wang S J, Chia L G, Hsu C Y, Lin W Y, Kao C H, Yeh S H
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan.
Clin Nucl Med. 1994 May;19(5):405-7. doi: 10.1097/00003072-199405000-00006.
Patients with Parkinson's disease often experience dysphagia, in which case food seems to be blocked in the throat. The patient must swallow over and over to get it down. A radionuclide solid phase esophageal motility study was conducted to evaluate esophageal function of patients with Parkinson's disease. Twenty-seven patients and 27 age-matched normal volunteers were studied. Each subject was placed in the supine position above a gamma camera linked to a computer and was given a 4 mL bolus of solid gelatin containing 75 MBq Tc-99m pertechnetate. Data were acquired in the list mode. A computer routine was used to calculate the total mean transit time, the residual fraction after the first swallow, and the retrograde index. The preliminary results suggest: 1) patients with Parkinson's disease display significantly slowed transit time when compared with normal age-matched controls, and 2) dysphagia of Parkinson's disease may improve with medication. A solid phase esophageal motility study may be used as a monitor of dysphagia in patients with Parkinson's disease in our future studies.
帕金森病患者常出现吞咽困难，在这种情况下，食物似乎会卡在喉咙里。患者必须反复吞咽才能将其咽下。进行了一项放射性核素固相食管动力研究，以评估帕金森病患者的食管功能。研究了27例患者和27名年龄匹配的正常志愿者。每个受试者仰卧在与计算机相连的γ相机上方，给予4毫升含75兆贝可高锝[99mTc]的固体明胶团块。数据以列表模式采集。使用计算机程序计算总平均通过时间、首次吞咽后的残留分数和逆行指数。初步结果表明：1）与年龄匹配的正常对照组相比，帕金森病患者的通过时间明显减慢；2）帕金森病的吞咽困难可能会通过药物治疗得到改善。在我们未来的研究中，固相食管动力研究可作为帕金森病患者吞咽困难的监测手段。
