Thorsby E, Solheim B G, Ottem A, Flatmark A, Enger E
Scand J Urol Nephrol. 1975(29 Suppl):7-10.
The influence of matching for the whole HLA haplotype as well as for the separate HLA antigens controlled by this region, was studied in a material of 98 living related and 178 cadaveric first transplants. Graft survival corresponded closely to the degree of HLA haplotype disparity between donor and recipient. Furthermore, graft survival was less in combinations being incompatible for the serologically defined HL-A and -B antigens as compared to compatible combinations. A weak MLC response between donor and recipient, even in the presence of HL-A and -B disparity, might signify prolonged graft survival.
在98例活体亲属供肾及178例尸体供肾首次移植的病例中，研究了整个HLA单倍型匹配以及由该区域控制的单个HLA抗原匹配的影响。移植肾存活情况与供体和受体之间HLA单倍型差异程度密切相关。此外，与血清学定义的HL-A和-B抗原不相容的组合相比，相容组合的移植肾存活时间更短。即使存在HL-A和-B抗原差异，供体和受体之间微弱的混合淋巴细胞反应可能意味着移植肾存活时间延长。
