内毒素对鸡胚的致死作用。
The lethal effect of endotoxins on the chick embryo.
作者信息
SMITH R T, THOMAS L
出版信息
J Exp Med. 1956 Aug 1;104(2):217-31. doi: 10.1084/jem.104.2.217.
Abstract
Inoculation of the CAM of the 10-day chick embryo with endotoxin preparations derived from the meningococcus and other Gram-negative microorganisms has been shown to result in multiple hemorrhages and death of the embryo within a few hours. Evidence has been presented to indicate that this lethal effect is specific for the general class of endotoxins derived from Gram-negative bacteria. Susceptibility to endotoxin was maximal in 10-day old embryos, and younger or older embryos showed little or no response. The optimal incubation temperature for the effect of endotoxin was 39.5 degrees C., and embryos incubated at 28 degrees C. were completely protected. The lethal effect was prevented by small amounts of cortisone, hydrocortisone, and 9-alpha fluorohydrocortisone, but not by cholesterol, desoxycorticosterone, or 1-dehydrocortisone.
摘要
用从脑膜炎球菌和其他革兰氏阴性微生物中提取的内毒素制剂接种10日龄鸡胚的绒毛尿囊膜，结果显示会在数小时内导致胚胎多处出血并死亡。已有证据表明，这种致死效应对于革兰氏阴性菌来源的内毒素这一类别具有特异性。10日龄胚胎对内毒素的敏感性最高，而较年轻或较年长的胚胎则几乎没有反应。内毒素发挥作用的最佳孵化温度为39.5摄氏度，在28摄氏度下孵化的胚胎则完全受到保护。少量的可的松、氢化可的松和9-α氟氢化可的松可预防致死效应，但胆固醇、脱氧皮质酮或1-脱氢可的松则不能。
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