Boldyrev A A, Stvolinskiĭ S L, Paskual' K, Romeĭ Sh, Del' Kastillo M D
Department of Clinical Biochemistry, National Research Center, Republic of Cuba.
Biokhimiia. 1992 Sep;57(9):1337-42.
The effects of hydrophilic antioxidant carnosine, trolox (6-hydroxy-2.5.7.8-tetramethylchroman-2-carboxylic acid), and superoxide dismutase on the myeloperoxidase activity of leukocytes, superoxide anion and active oxygen species generation have been studied. Physiological concentrations of carnosine have been shown to decrease the ability of human leukocytes to produce chemiluminescence as a result of myeloperoxidase activation. However, the chemiluminescence induced by the generation of the superoxide or its derivatives is unaffected by this process. Trolox does not inhibit the induction of superoxide-dependent chemiluminescence of leukocytes either.
已研究了亲水性抗氧化剂肌肽、生育三烯酚（6-羟基-2,5,7,8-四甲基色满-2-羧酸）和超氧化物歧化酶对白细胞髓过氧化物酶活性、超氧阴离子生成及活性氧物种产生的影响。研究表明，生理浓度的肌肽可降低人类白细胞因髓过氧化物酶激活而产生化学发光的能力。然而，由超氧阴离子或其衍生物生成所诱导的化学发光不受此过程影响。生育三烯酚也不抑制白细胞超氧阴离子依赖性化学发光的诱导。
