Lavandero S, Martínez S, Guarda E, Corbalán R, Cartagena G, Jalil J E, Foncea R, Ebensperger R, Godoy I, Casanegra P
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
Rev Esp Cardiol. 1992 Oct;45(8):525-30.
We have previously corroborated that lymphocyte beta-adrenergic receptor density is significantly reduced in patients with chronic heart failure. It is well known that angiotensin converting enzyme inhibitors normalize the function of sympathetic nervous system. We have assessed the effect of enalapril on lymphocyte beta-adrenergic receptor system from patients with chronic heart failure (n = 14) using a random, cross and double blind protocol. Our results show that the improvement in clinical score and ventricular function were not related with changes in the number and affinity of beta-adrenergic receptor nor cyclic AMP content in lymphocytes obtained from these patients.
我们之前已经证实，慢性心力衰竭患者的淋巴细胞β-肾上腺素能受体密度显著降低。众所周知，血管紧张素转换酶抑制剂可使交感神经系统功能恢复正常。我们采用随机、交叉和双盲方案，评估了依那普利对慢性心力衰竭患者（n = 14）淋巴细胞β-肾上腺素能受体系统的影响。我们的结果表明，这些患者临床评分和心室功能的改善与β-肾上腺素能受体数量和亲和力的变化以及淋巴细胞中环磷酸腺苷含量的变化无关。
