Abrahamsen B, Christiansen B D
Medicinsk afdeling, Varde Sygehus.
Ugeskr Laeger. 1992 Dec 7;154(50):3602-3.
Developed for the treatment of migraine, sumatriptan is an agonist of 5-hydroxytryptamine-1-receptors. Though a pressure sensation is a common complaint, significant ECG changes have not been reported after subcutaneous administration of sumatriptan. A case history is given where angina pectoris after sumatriptan self-administration was experienced on two occasions by a 61-year old man with a history of minor myocardial infarction--without post-infarction angina--two years previously. The angina after sumatriptan was accompanied on both occasions by significant ST-segment depression on ECG-monitoring. An extracranial vasoconstrictor action of sumatriptan in patients with ischaemic heart disease is suggested.
舒马曲坦是一种5-羟色胺-1-受体激动剂，用于治疗偏头痛。虽然有压迫感是常见的主诉，但皮下注射舒马曲坦后尚未报告有显著的心电图变化。本文给出了一个病例史，一名61岁男性有轻微心肌梗死病史（两年前发生，无梗死后期心绞痛），两次自行服用舒马曲坦后均出现心绞痛。两次服用舒马曲坦后的心绞痛发作时，心电图监测均伴有显著的ST段压低。提示舒马曲坦对缺血性心脏病患者有颅外血管收缩作用。
