Sheng H, Hughes M L, Murad F, Briggs C A
Signal Transduction, Abbott Laboratories, IL 60064.
Brain Res. 1992 Dec 4;597(2):343-5. doi: 10.1016/0006-8993(92)91492-w.
Preganglionic nerve stimulation in the rat superior cervical ganglion (SCG) caused an increase in guanosine 3':5'-cyclic monophosphate (cyclic GMP) in a Ca(2+)-dependent manner. This increase was inhibited by oxyhaemoglobin, and blocked stereoselectively by an inhibitor of nitric oxide synthase, NG-nitro-L-arginine. Thus, nitric oxide or a similar substance appears to mediate the neuronal cyclic GMP response to synaptic activity in the rat SCG.
对大鼠颈上神经节（SCG）的神经节前神经刺激，以钙依赖的方式引起3':5'-环磷酸鸟苷（环鸟苷酸）增加。这种增加被氧合血红蛋白抑制，并被一氧化氮合酶抑制剂NG-硝基-L-精氨酸立体选择性阻断。因此，一氧化氮或类似物质似乎介导了大鼠颈上神经节中神经元环鸟苷酸对突触活动的反应。
