老年新西兰黑鼠中对DNA迟发型超敏反应的自发发生。
Spontaneous occurrence of delayed hypersensitivity to DNA in old NZB mice.
作者信息
Pekárek J, Svejcar J, Rovenský J, Zitńan D
出版信息
Z Immunitatsforsch Exp Klin Immunol. 1975 Nov;150(5):384-8.
PMID:133543
Abstract
The sensitivity of NZB/Bl and NZB/Swiss Fl hybride mice spleen lymphocytes to DNA was examined using the MIF production and inhibition of migration from artificial fragment. The positivity was found in the group of old mice which was considered as an indication of spontaneous autoimmune process. The possible mechanism of this process is discussed.
摘要
利用巨噬细胞移动抑制因子（MIF）的产生及对人工片段迁移的抑制作用，检测了新西兰黑鼠（NZB/Bl）和新西兰黑鼠与瑞士小鼠杂交一代（NZB/Swiss F1）小鼠脾淋巴细胞对DNA的敏感性。在老年小鼠组中发现了阳性结果，这被认为是自发自身免疫过程的一个指标。文中讨论了这一过程的可能机制。
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