β-肾上腺素能拮抗剂对心血管疾病发病率和死亡率的影响。
The effect of beta-adrenoreceptive antagonists on the morbidity and mortality in cardiovascular disease.
作者信息
Fitzgerald J D
出版信息
Postgrad Med J. 1976 Dec;52(614):770-81. doi: 10.1136/pgmj.52.614.770.
Abstract
The effect is critically reviewed of chronic administration of beta-adrenoreceptor antagonists on morbidity and mortality in angina pectoris and myocardial infarction. There is inconclusive evidence that the abrupt cessation of therapy with these agents may increase morbidity and mortality in angina pectoris. The type of anginal patient in which this may occur is not yet defined and neither is the mechanism. There is no evidence that beta-antagonists prolong the life of anginal patients. In the acute phase of experimental myocardial infarction, these drugs reduce mortality but do not do so in man. There is increasing evidence that they prolong life if administered to patients surviving the acute phase of myocardial infarction. The need for further studies is discussed.
摘要
对β-肾上腺素能受体拮抗剂长期给药对心绞痛和心肌梗死患者发病率和死亡率的影响进行了严格审查。尚无确凿证据表明突然停用这些药物会增加心绞痛患者的发病率和死亡率。可能出现这种情况的心绞痛患者类型尚未明确，其机制也不清楚。没有证据表明β受体拮抗剂能延长心绞痛患者的寿命。在实验性心肌梗死的急性期，这些药物可降低死亡率，但在人类患者中并非如此。越来越多的证据表明，对心肌梗死急性期存活的患者给药，这些药物可延长其寿命。文中讨论了进一步研究的必要性。
相似文献
1
The effect of beta-adrenoreceptive antagonists on the morbidity and mortality in cardiovascular disease.β-肾上腺素能拮抗剂对心血管疾病发病率和死亡率的影响。
Postgrad Med J. 1976 Dec;52(614):770-81. doi: 10.1136/pgmj.52.614.770.
2
Beta-adrenergic blockade for survivors of acute myocardial infarction.急性心肌梗死幸存者的β-肾上腺素能阻滞剂治疗
N Engl J Med. 1984 Mar 29;310(13):830-7. doi: 10.1056/NEJM198403293101306.
3
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.β-肾上腺素能阻滞剂在心肌梗死患者中的应用。
Curr Probl Cardiol. 1984 Jun;9(3):1-50. doi: 10.1016/0146-2806(84)90015-x.
4
Beta-Blockers in the management of myocardial ischemia.
Adv Cardiol. 1974;13:315-29. doi: 10.1159/000395544.
5
[Preventive effects of beta-blockers on myocardial infarction and on cardiac accidents following a first infarct].β受体阻滞剂对心肌梗死及首次心肌梗死后心脏意外事件的预防作用
Nouv Presse Med. 1978 Sep 20;7(31):2741-5.
6
Beta-adrenergic receptor blocking drugs in angina pectoris.β-肾上腺素能受体阻滞剂在心绞痛中的应用。
Drugs. 1974;7(1):55-84. doi: 10.2165/00003495-197407010-00005.
7
The role of long term beta-blockade after myocardial infarction: Paper 3.心肌梗死后长期β受体阻滞剂的作用：论文3。
Aust Fam Physician. 1978 Jun;Suppl:38-9.
8
Beta blocking agents: current status in the prevention of sudden coronary death.β受体阻滞剂：预防冠心病猝死的现状
Ann N Y Acad Sci. 1982;382:305-23. doi: 10.1111/j.1749-6632.1982.tb55226.x.
9
Beta-blockers and myocardial infarction: infarction and ischaemia in the practolol and propranolol trials.
Aust N Z J Med. 1983 Apr;13(2):181-2. doi: 10.1111/j.1445-5994.1983.tb02679.x.
10
[Clinical application of beta-blockaders].[β受体阻滞剂的临床应用]
Ned Tijdschr Geneeskd. 1973 May 26;117(21):814-21.
引用本文的文献
1
Points arising from discussion.讨论中提出的要点。
Proc R Soc Med. 1977;70(Suppl 5):15-6. doi: 10.1177/00359157770700S507.
2
Low-dose propranolol for the protection of the left ventricle from ischaemic damage.低剂量普萘洛尔用于保护左心室免受缺血性损伤。
Thorax. 1981 Nov;36(11):814-22. doi: 10.1136/thx.36.11.814.
3
Propranolol and beta-adrenergic receptor blocking drugs in the treatment of hypertension.普萘洛尔及β-肾上腺素能受体阻断药治疗高血压
Br J Clin Pharmacol. 1982 Jan;13(1):51-60. doi: 10.1111/j.1365-2125.1982.tb01336.x.
4
The management of hypertension.高血压的管理
Br J Clin Pharmacol. 1986;21 Suppl 2(Suppl 2):129S-142S. doi: 10.1111/j.1365-2125.1986.tb02862.x.
5
The second Lilly Prize Lecture, University of Newcastle, July 1977. beta-Adrenergic receptor blockade in hypertension, past, present and future.第二届礼来奖讲座，纽卡斯尔大学，1977年7月。高血压中的β-肾上腺素能受体阻断：过去、现在与未来。
Br J Clin Pharmacol. 1978 May;5(5):379-99. doi: 10.1111/j.1365-2125.1978.tb01644.x.
6
Recommending coronary artery surgery: refining judgement through application of new knowledge.推荐冠状动脉手术：通过应用新知识来完善判断。
Postgrad Med J. 1976 Dec;52(614):782-7. doi: 10.1136/pgmj.52.614.782.
本文引用的文献
1
The sympathogenic biochemical trigger mechanism of angina pectoris. Its therapeutic suppression and long-range prevention.
Am J Cardiol. 1962 Apr;9:576-90. doi: 10.1016/0002-9149(62)90077-2.
2
Plasma catechol amine concentrations in myocardial infarction and angina pectoris.心肌梗死和心绞痛患者血浆儿茶酚胺浓度
Circulation. 1959 May;19(5):657-61. doi: 10.1161/01.cir.19.5.657.
3
Free noradrenaline and adrenaline excretion in relation to clinical syndromes following myocardial infarction.心肌梗死后游离去甲肾上腺素和肾上腺素排泄与临床综合征的关系。
Am J Cardiol. 1967 Nov;20(5):605-17. doi: 10.1016/0002-9149(67)90001-x.
4
Beta-adrenergic blockade in experimental myocardial infarction.实验性心肌梗死中的β-肾上腺素能阻断
Am Heart J. 1966 Dec;72(6):790-6. doi: 10.1016/0002-8703(66)90162-1.
5
Treatment of acute myocardial infarction with propranolol.用普萘洛尔治疗急性心肌梗死。
Am J Cardiol. 1966 Sep;18(3):458-62. doi: 10.1016/0002-9149(66)90070-1.
6
Protective influence of cardiac denervation against arrhythmias of myocardial infarction.心脏去神经支配对心肌梗死心律失常的保护作用。
Cardiovasc Res. 1969 Jul;3(3):241-4. doi: 10.1093/cvr/3.3.241.
7
Prevention of ventricular fibrillation induced by coronary ligation.预防冠状动脉结扎诱发的心室颤动。
J Pharmacol Exp Ther. 1968 Dec;164(2):326-32.
8
The induction of arrhythmias by sympathetic activity before and after occlusion of a coronary artery in the canine heart.犬心冠状动脉闭塞前后交感神经活动诱发心律失常的情况。
J Electrocardiol. 1971;4(1):34-43. doi: 10.1016/s0022-0736(71)80048-1.
9
The sequential estimation of plasma catecholamines and whole blood histamine in myocardial infarction.
Am Heart J. 1971 Aug;82(2):171-9. doi: 10.1016/0002-8703(71)90262-6.
10
Urinary excretion of catecholamines and their main metabolites after myocardial infarction; relationahip to the clinical syndrome.心肌梗死后儿茶酚胺及其主要代谢产物的尿排泄；与临床综合征的关系。
Eur J Clin Invest. 1970 Aug;1(2):77-83. doi: 10.1111/j.1365-2362.1970.tb00600.x.
Zotero 插件