Brown A H, Krause B L, Morritt G M
Thorax. 1981 Nov;36(11):814-22. doi: 10.1136/thx.36.11.814.
Global myocardial ischaemia improves intracardiac operating conditions but damages the myocardium. Propranolol should reduce this damage but may impair postoperative myocardial contractility. An assessment of its protective effect during 90 minutes of normothermic ischaemia in canine hearts has been made. The early and late changes of contractility caused by low-dose propranolol were also recorded. A comparison of cardiac isovolumic contractile force, velocity, and compliance was made in three groups of dogs given 30 microgram/kg of propranolol with or without 90 minutes of cardiac ischaemia, or cardiac ischaemia without propranolol. Contractile force and velocity were significantly reduced by the propranolol, but recovered fully after 90 minutes. Ischaemia without propranolol reduced force and velocity of contraction significantly more than ischaemia with propranolol. Propranolol thus reduces operative ischaemic damage without itself impairing postoperative function.
全身性心肌缺血可改善心内手术条件，但会损害心肌。普萘洛尔应能减轻这种损害，但可能会削弱术后心肌收缩力。已对其在犬心常温缺血90分钟期间的保护作用进行了评估。还记录了低剂量普萘洛尔引起的收缩力早期和晚期变化。对三组犬进行了比较，分别给予30微克/千克普萘洛尔，有或无90分钟心脏缺血，或无普萘洛尔的心脏缺血，比较心脏等容收缩力、速度和顺应性。普萘洛尔使收缩力和速度显著降低，但90分钟后完全恢复。无普萘洛尔的缺血比有普萘洛尔的缺血使收缩力和速度降低得更显著。因此，普萘洛尔可减轻手术缺血损伤，而自身不会损害术后功能。
