Kweifio-Okai G, Macrides T A
Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora, Australia.
Res Commun Chem Pathol Pharmacol. 1992 Dec;78(3):367-72.
Triterpenes--alpha-amyrin acetate, beta-amyrin acetate and beta-amyrin were tested for their effects on the synthesis of 5-lipoxygenase products in human neutrophils. All the triterpenes reduced 5-HETE synthesis without effect on LTB4 synthesis. The relative effects suggest that 5-HETE inhibition can explain the antiarthritic activity possessed by these compounds.
测试了三萜类化合物——乙酸α-香树脂醇、乙酸β-香树脂醇和β-香树脂醇对人中性粒细胞中5-脂氧合酶产物合成的影响。所有三萜类化合物均降低了5-羟基二十碳四烯酸（5-HETE）的合成，而对白三烯B4（LTB4）的合成没有影响。这些相对作用表明，5-HETE抑制作用可以解释这些化合物所具有的抗关节炎活性。
