甲型肝炎病毒疫苗诱导抗体的持久性。

Persistence of vaccine-induced antibody to hepatitis A virus.

作者信息

Wiedermann G, Ambrosch F, André F E, D'Hondt E, Delem A, Safary A

机构信息

Institute for Specific Prophylaxis and Tropical Medicine, Vienna, Austria.

出版信息

Vaccine. 1992;10 Suppl 1:S129-31. doi: 10.1016/0264-410x(92)90566-3.

DOI:10.1016/0264-410x(92)90566-3

PMID:1335643

Abstract

A level of 10 mIU hepatitis A antibodies/ml as measured by ELISA is believed to be the minimal protective concentration. If this level is considered, the mean persistence of vaccine induced antibodies is approximately 10-11 years after booster dose, 6-7 years if only the primary doses are given and 5-6 years if the minimal individual titre is taken into account.

摘要

通过酶联免疫吸附测定法测得的甲型肝炎抗体水平为10 mIU/ml被认为是最低保护浓度。若考虑这一水平，加强剂量后疫苗诱导抗体的平均持续时间约为10至11年；若仅接种初免剂量，则为6至7年；若考虑最低个体滴度，则为5至6年。